Is a low- starch diet the solution? Do you have an autoimmune disease? Do starchy foods tend to make your symptoms worse? Mounting evidence suggests that individuals who have autoimmunity related to a particular set of genes called HLA- B2. Read on to learn why this is and if a low- starch diet is right for you. Numerous environmental factors have been implicated in the development of autoimmune disease, including antibiotic use, birth by cesarean section, chemical exposure, poor diet, and sleep deprivation, among others (1, 2, 3, 4, 5). While it is widely believed that disease onset requires an environmental trigger, most autoimmune conditions have a genetic component as well (6). Genetic information can be a powerful tool in aiding both diagnosis and treatment. Probiotics are live bacteria and yeasts that are good for your health, especially your digestive system. We usually think of bacteria as something that causes. If you want to take a deep dive, Dr. Gonzalez masterfully dismantles the ketogenic diet for cancer in the lengthy article below. This is not a scientific rebuttal. Cochrane works collaboratively with contributors around the world to produce authoritative, relevant, and reliable evidence, in the form of Cochrane Reviews. CAM & Life Style > M - R. Last Update: 01/03/2015. TOPICS Macrobiotic diet ? One particular group of genes that has been strongly associated with various autoimmune diseases is HLA- B2. In this article, I’ll discuss HLA- B2. ![]() ![]() Klebsiella, and why a low- starch diet may be effective for those who have an HLA- B2. What’s this about HLA? HLA is short for human leukocyte antigen. Putting it together, HLA is essentially a group of genes that determine which proteins are present on the surface of your immune cells. Humans have a total of 2. You therefore inherit one set of HLA genes from your mother and one from your father, on the maternal and paternal versions of chromosome 6. HLA is a highly polymorphic gene, meaning there are many different possible gene set variants, or “haplotypes,” that you can have. The astounding number of haplotypes for HLA likely evolved to allow for the fine- tuning of the human adaptive immune system, but certain haplotypes can also predispose an individual to a particular disease of the immune system. You may have read my previous article in which I mentioned the role of HLA haplotypes in susceptibility to mold illness. HLA- DQ haplotypes have also been associated with celiac disease (7), while HLA- DRB1 has been associated with rheumatoid arthritis (8). For the remainder of this article, I’ll focus on HLA- B2. The genetic link between autoimmune disease and dietary starch. HLA- B2. 7 is associated with various autoimmune diseases. The prevalence of HLA- B2. Only 8 percent of Caucasians, 4 percent of North Africans, 2 to 9 percent of Chinese, and 0. Japanese people possess HLA- B2. The most closely associated autoimmune disease with HLA- B2. AS), an inflammatory disease in which some of the vertebrae of the spine fuse together, inhibiting mobility. ![]() ![]() An estimated 8. 8 percent of people with AS are HLA- B2. HLA- B2. 7- positive people will develop AS (1. Advanced glycation end products (AGEs) are a complex group of compounds formed when sugar reacts with amino acids. This can occur both in the food you. Scientific Facts Proving Charles Darwin's Theory of Evolution is Wrong, False, and Impossible. News You Can Use. Hi, my name is Evolutionary Fraud from Piltdown, England. ![]() Other autoimmune diseases that are associated with an HLA- B2. Crohn’s disease, ulcerative colitis, psoriasis, reactive arthritis, and uveitis (1. Making things a bit more complicated, HLA- B2. These are distinguished by a two- digit number added to the “parent” haplotype. Many of the most common subtypes of HLA- B2. B2. 70. 4 and B2. AS, while other subtypes (like HLA B2. B2. 70. 9) actually appear to be protective against the disease (1. This is likely due to the structure of the protein encoded by the HLA gene, as we’ll explore more in the next section. The Klebsiella connection. As early as 1. 98. AS patients were identified as having elevated levels of serum Ig. A, suggesting the abnormal movement of microbes from the gut into the bloodstream (1. More recently, microbiome analyses identified greater abundance of a gram- negative bacterium called Klebsiella in stool samples of patients with AS (1. Fitting with their hypothesis of bacterial influx into the bloodstream, researchers found that these patients also had elevated levels of anti- Klebsiella antibodies in the blood (1. Biochemical studies have found that Klebsiella have two molecules that carry sequences that closely resemble HLA- B2. Scientists have hypothesized that this “molecular mimicry” allows for cross- reactivity. In other words, the immune system produces antibodies against Klebsiella in an effort to remove it from the bloodstream, but these antibodies can also “accidentally” bind to HLA- B2. This idea of antibodies binding to “self” is characteristic of autoimmunity. Although Klebsiella is one of the most widely studied microorganisms in relation to HLA- B2. For example, Proteus bacteria have been suggested to be involved in the development of rheumatoid arthritis via the same molecular mimicry mechanism as Klebsiella (2. As we’ll see next, knowledge of these mechanisms and the bacteria involved can really help shape our approach to treatment. Why a low- starch diet might help. The composition of the gut microbiota is constantly shaped by the influx of dietary substrates (2. ![]() Within carbohydrates, substrates can be further categorized as simple sugars and polysaccharides like starch or cellulose. Biochemical studies of Klebsiella have shown that this bacterium does not grow on cellulose derived from plants but can grow readily on more simple sugars (2. Most simple sugars like glucose are absorbed in the proximal small intestine and therefore do not travel as far as the large intestine, where the majority of microbes are located. Simple sugars from the diet are therefore unavailable to Klebsiella. Starch, however, is not as easily digested or absorbed, and some of it remains intact when foodstuffs finally reach the colon. Klebsiella have been shown to manufacture pullulanase, a starch- debranching enzyme, that enables them to break down starch into simple sugars for energy and growth (2. Several studies have applied this information in humans. One randomized control trial split people into two groups: a high- carbohydrate, low- protein diet or a low- carbohydrate, high- protein diet. They then compared the abundance of Klebsiella in fecal samples. The average number of Klebsiella was 3. Another study found that a low- starch diet reduced total serum Ig. A in AS patients (2. The majority of these patients also reported a decline in symptom severity and, in some cases, complete remission. Take steps toward remission. Now that you better understand the science behind HLA- B2. Find out your haplotype. Currently, there is no readily available, user- friendly means of determining HLA haplotype from full genomic sequencing data (from companies like 2. While there are a few HLA- related SNPs that can be identified in the raw genetic data, at best these are only correlated with HLA haplotype and do not provide information about subtype. The best and most accurate way to determine your haplotype is to request a blood test from your healthcare practitioner that uses a more targeted DNA sequencing approach to identify which alleles you carry (2. Experiment with your starch/carb intake. Even if you don’t have access to genetic testing, or if you’re HLA- B2. I am a big proponent of n=1 experimentation and finding the diet that is right for you. Eileen Laird of Phoenix Helix has written an excellent post in which she shares the results of her own and several other Paleo autoimmune bloggers’ starch experiments. Many found that they can tolerate some forms of starch but not others. This is really valuable, since we know that a diet devoid of fermentable fiber like starch can be detrimental to the long- term health of the gut microbiota (2. Heal your gut. At the risk of sounding like a broken record, healing the gut is absolutely critical to achieving and maintaining optimal health. A leaky gut allows bacteria and dietary proteins into the bloodstream, which provokes an immune response. Regardless of your HLA haplotype, strengthening the integrity of the intestinal barrier is an important step towards achieving remission. Supporting a diverse, healthy microbiota can also help to keep Klebsiella and other potentially problematic microbes at bay. Now I’d like to hear from you. Do you know your HLA haplotype? Have you noticed a change in your autoimmune disease symptoms by increasing or decreasing your starch intake? Share your experience in the comments section below. Like what you’ve read? Sign up for FREE updates delivered to your inbox. I hate spam too. Your email is safe with me.
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